Paper
Anti-obesity Activity of Peucedanum Japonicum Thunb Extract in Obese Diabetic Animal Model C57BL/6J Ham Slc-ob/ob Mice
- Authors:
- Hirosuke Oku; Hironori Iwasaki; Masashi Inafuku; Takayoshi Toda; Takafumi Okabe; Natthanan Nukitrangsan
- Abstract
- Aim of the studyis to evaluate the anti-diabetic activity of PJT.This study examined its anti-obesity activity in obese-diabetic animal model of C57BL/6J Ham Slc-ob/obmice.Bydividing animals into control and ethanol extract of PJT groups, body weight gain, tissue weight, biochemical parameters in serum, liver, fecal lipid concentrations and gene expression in the tissues were compared between control and PJT extract groups after been fed with the basal low-fat diet supplemented with or without PJT extract for four weeks.The resultsshow that supplementation of the diet with ethanol extract of PJT significantly reducedwhite adipose tissue (WAT), serum triglyceride (TG), total cholesterol (TC) andadipocyte size. The ethanol extractsalso significantly increase insulin sensitivity, fecalexcretion of TG, TC, and decreased that of bile acid. The ethanol extract of PJT modulated the obesity related genes in liver, adipose tissues of ob/ob mice: upregulationof PBEF1, PPARα, and downregulation of FAS genes in the liver; upregulation of RORC,DGAT1, FXRα, PPARγ genes in the adipose tissue; increased expression of CPT1α,UCP2 and GLUT4 genes in muscle.In conclusion,it issuggested that ethanol extract of PJT exerted anti-diabeticactivitythrough the modulation of obesity-related lipid parameters in obese-diabeticanimal model.
- Keywords
- Anti-obesity; C57BL/6J Ham Slc-ob/ob Mice; Lipid Metabolism; GeneExpression; Ethanol Extract of Peucedanum japonicum Thunb
- StartPage
- 28
- EndPage
- 34
- Doi
- 10.5963/LSMR0202004