Paper
Synthesis of Calcium bis-(E)-3,5-dihydroxy-7-[4’-(4’’-flurophenyl)-2’-cyclopropyl-quinoline-3-yl]-hept-6-enoate a HMG-CoA Reductase Inhibitor via Novel Acetonide Intermediate
- Authors:
- Kundan Singh Shekhawat; D K Sharma
- Abstract
- Calcium bis-(E)-3,5-dihydroxy-7-[4’-(4’’-flurophenyl)-2’-cyclopropyl-quinoline-3-yl]-hept-6-enoate 1 a HMG-CoA reductase inhibitor via novel acetonide intermediate 2, were synthesized. The operational simplicity, high purity, eco-friendly conditions and easily scalable process are major benefits of this process. The starting material 3 employed for the preparation were synthesized by known literature method[1].
- Keywords
- Acetonide; HMG-CoA Reductase; Pitavastatin Calcium; Deprotectio; Hydrolysis
- StartPage
- 88
- EndPage
- 94
- Doi