Paper
Synthesis of Calcium bis-(E)-3,5-dihydroxy-7-[4’-(4’’-flurophenyl)-2’-cyclopropyl-quinoline-3-yl]-hept-6-enoate a HMG-CoA Reductase Inhibitor via Novel Acetonide Intermediate
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Authors:
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Kundan Singh Shekhawat; D K Sharma
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Abstract
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Calcium bis-(E)-3,5-dihydroxy-7-[4’-(4’’-flurophenyl)-2’-cyclopropyl-quinoline-3-yl]-hept-6-enoate 1 a HMG-CoA reductase inhibitor via novel acetonide intermediate 2, were synthesized. The operational simplicity, high purity, eco-friendly conditions and easily scalable process are major benefits of this process. The starting material 3 employed for the preparation were synthesized by known literature method[1].
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Keywords
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Acetonide; HMG-CoA Reductase; Pitavastatin Calcium; Deprotectio; Hydrolysis
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StartPage
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88
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EndPage
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94
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Doi
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