Paper
Correlation of the Rate of Solvolysis of Neopentyl Fluoroformate and a Consideration of Alkyl Haloformates in Solvolytic Reactions
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Authors:
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Dennis N. Kevill; Jin Burm Kyong; Kyoung-Ho Park; Mi Hye Seong
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Abstract
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The specific rates of solvolysis of neopentyl fluoroformate (NeopOCOF, 1) have been measured at 45.0 oC in pure and binary solvent mixtures. These results correlated well with the extended Grunwald-Winstein equation in all of the solvents except the four TFE-ethanol binary solvents. Leaving group effects (kF/kCl values) and sensitivity (l and m values) to changes in solvent nucleophilicity and solvent ionizing power are appreciably similar to those observed previously for the solvolyses of primary and secondary alky haloformates. This is consistent with the addition-elimination pathway as rate-determining. The kinetic solvent isotope effects (KSIEs, kMeOH/kMeOD) and activation parameters for the solvolyses of 1 were also determined. The results are compared with those reported earlier for neopentyl chloroformate (NeopOCOCl, 2) and other alkyl haloroformate esters.
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Keywords
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Neopentyl Fluoroformate; Grunwald–Winstein Equation; Leaving Group Effect; Solvolytic Reaction; Addition-Elimination Pathway
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StartPage
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70
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EndPage
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76
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Doi
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