Paper
Studies of Complex Magnetic Nanoparticles with Anticancer Agents for Cancer Therapy
- Authors:
- Igor Schepotin; Sergey Lukin; Anatoliy Burlaka; Marina Tselepi; Crispin Barnes; Andriy Romanov; Thanos Mitrelias; Valerii Orel; Anatoliy Shevchenko
- Abstract
- An impressive increase in the survival rates of rats infected with Guerin carcinoma has been demonstrated, following the injection of complex magnetic nanoparticles (abbreviated as MCN) to induce hyperthermia and targeted drug delivery. Here, we present the latest developments in our technology for the synthesis of MCN comprising magnetite nanoparticles Fe3O4 and molecules of the anticancer drug anthracycline antibiotic doxorubicin (DR) with KCl. MCN were synthesized in a mechanic reactor with magnetic elements, by magneto-mechano-chemical dry synthesis. DR and its nanocarrier Fe3O4 with KCl were subjected to mechanical activation. It is demonstrated that under the influence of mechano-chemical and magneto-mechano-chemical synthesis of the MCN, the concentration of paramagnetic centers increased. In pilot preclinical studies we showed that following the injection of the MCN synthesized by our methods, into rats with Guerin carcinoma subjected to external electromagnetic radiation, the survival rates increased by 25% as compared to the treatment with conventional DR alone.
- Keywords
- Magneto-Mechano-Chemical Synthesis; Reactor; Magnetic Nanoparticles; Magnetic Moment; Paramagnetic Centers; Free Radicals; Doxorubicin; Guerin Carcinoma
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- EndPage
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