Paper
Structural Stability of Dodecylphosphocholine Liposome on the Polypropylene Surface
- Authors:
- Daixi Li; Baolin Liu
- Abstract
- Liposomes as a kind of targeting medicine carrier are investigated by scientists all over the world. However, the instability of liposomes often limits their application. In order to probe the rationale at the molecular level for such instability, the adsorption of dodecylphosphocholine liposomes on the polypropylene surface was researched by using molecular simulation. Two types of polypropylene surfaces and a 65-dodecylphosphocholine liposome were constructed. One surface composed of horizontal polypropylene molecules (each containing 40 propylene units) was used to represent a perfectly crystallized surface. And the other surface composed of vertical polypropylene molecules (each contained 10 propylene units) was used to represent an amorphous surface. The above systems were both performed for 10ns by using the Gromacs software in order to investigate the stability of solvated liposome in polymer containers. The simulation results show that the dodecylphosphocholine liposome is instable on the polypropylene surface no matter which kind of surface it is. In summary, the liposome of dodecylphosphocholine should not be preserved in such kind of polymer containers.
- Keywords
- Liposome; Structural Stability; Polypropylene; Molecular Simulation; Intermolecular Interaction
- StartPage
- 8
- EndPage
- 12
- Doi