Paper
Negative Feedback Effect in HIV Progression: An Optimal Control Theoretic Approach
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Authors:
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Priti Kumar Roy; Amar Nath Chatterjee; Sutapa Biswas Majee
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Abstract
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Long-term infection by Human Immunodeficiency Virus produces a multitude of clinical symptoms resulting in total suppression of the immune system dominated by depletion in CD4+ T cell count and reduction in density of Human Immunodeficiency Virus specific Cytotoxic T-Lymphocyte immune responses. Since the dynamics between viral infection and replication parameters and the host immunity system changes from short-term to long-term chronic infection, mathematical modeling of long-term dynamics necessitates incorporation of negative feedback control mechanism. By applying optimal control theory approach to the administration of combination therapy of reverse transcriptase inhibitor and interleukin 2 in the same model, the most cost-effective strategy has been established where maximum recovery of CD4+ T cell population is attained.
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Keywords
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Human Immunodeficiency Virus; Host Immune System; Negative Feedback Control; Optimal Control
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StartPage
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1
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EndPage
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12
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Doi
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