Paper
Immune Cell Response to Negative Feedback Effect on HIV
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Authors:
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Priti Kumar Roy; Amar Nath Chatterjee; Sutapa Biswas Majee
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Abstract
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Alteration in host-virus interaction dynamics during long-term
infection by HIV necessitates consideration of inverse relationship between
high viral load and density of CTL response leading to dysregulation of
host immunity system. Mathematical modeling introducing negative feedback
control mechanism helps in establishment of threshold condition for
disease eradication as well as necessary conditions for existence of different
equilibria depending on values of basic reproduction ratio. Moreover, IL-2
adjuvenated HAART therapy has been found to be highly cost-effective in
recovery of the immunity status in the present mathematical model using
negative feedback effect.
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Keywords
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HIV, CD4+T Cells, CTL, Negative Feed Back Control, HAART, IL-2
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StartPage
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37
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EndPage
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47
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Doi
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10.5963/BER0201005