Paper
Modeling The Dynamics Of Amyloid Formation Of Islet Beta Cells Under Therapeutic Interventions And Its Role In Discovery Of Novel Target For Drug Action
- Authors:
- Murali Raman; Padma Murali
- Abstract
- Islet Amyloid Polypeptide (IAPP or amylin) is a protein which was first discovered in the year 1987. It is coexpressed and cosecreted in the beta islet cells of the pancreas along with insulin. IAPP forms amyloid plaques in diseased states like type II diabetes mellitus (T2DM) and Hypertension. These comorbidities play an important role in development of cardiovascular diseases(CVD). Thus, control of amyloidosis is vital in prevention and management of T2DM and CVD. In this work, we model the dynamics of amyloid formation of islet beta cells under therapeutic interventions. According to this model the effects of drug therapy on amyloid formation are given by a system of ordinary differential equations and a partial differential equation. The model is then converted into a system of ordinary differential equations and the equilibrium points are computed and their stability is studied. Also, numerical simulations are performed on the model and we conclude that amyloidosis can be controlled in the presence of therapeutic intervention.
- Keywords
- IAPP; Diabetes Mellitus; Drug Therapy; CVD; Hypertension
- StartPage
- 1
- EndPage
- 10
- Doi
- 10.5963/LSMR0301001