Volume 2 Issue 3
Authors: Mana Sezdi
Abstract: The objective of this study is to investigate the performance of the medical devices by analyzing the problems of the medical devices that do not meet the international standards. The data used in this study were obtained by interpreting of the performance test results of medical devices. The study includes high risk group medical devices used at the departments of operation room and intensive care in Cerrahpasa Faculty of Medicine in Istanbul University. The performance tests of total 542 medical devices were performed and the measurement results were interpreted according to the Inspection and Preventive Maintenance System (IPM) procedures which were developed by Emergency Care Research Institute (ECRI). The obtained data were analyzed and the results were given in graphics. This study showed that the controlling of the performance of the medical devices especially the high risk group medical devices in the hospital will be helpful in quality assurance studies. As a result of this, a preventive maintenance program was created. Thus, tracing the problems before they happen and stocking required spare parts were made possible. Additionally, the analysis of the medical devices according to the manufacturer helped us to decide the right during the purchasing of the new devices.
Keywords: Performance Test; Preventive Maintenance; Quality Management; Risk Analysis
Authors: Andrey Belousov
Abstract: In an experiment it is shown on rats, that biocompatible standardized nanoparticles of ICNB can be effectively used at MRI. It is well-proven that nanoparticles of ICNB for certain (р<0.001) strengthen a contrasting effect at MRI. Methodology of safe intravenous application of ICNB is excluding the use of magnetite of nanoparticles in the variant of independent contrasting means at MRI. It is set that in 24 hours after intravenous inject of ICNB the magnetite of nanoparticles for certain (p<0.001) selectively accumulate in tissue of malignant tumour and rise brightness of image. On 4th days investigation the dynamics of reduction of brightness of image in tumour and muscles was establishment for certain (р<0.001). This fact is caused by process eliminating of nanoparticles from organism of rat. On the mechanism of action the nanoparticles of ICNB cause the convertible changes which is reason for the temporal increase of mobility of protons of hydrogen in near cell liquid. It inevitably modifies the metabolic process in malignant cells that in perspective has hope in elaborating new ways of the target therapy of malignant neoplasm.
Keywords: Nanoparticles; Magnetic; ICNB; MRI; Malignant Tumour; Contrast; Selectively
Authors: Kenkichi Ohba; Tsutomu Tajikawa; Shimpei Kohri
Abstract: A novel, less invasive, miniaturized fiber-optic laser Doppler velocimetry (LDV) sensor, which can be directly inserted into a blood vessel was developed for clinical use in measurements of local blood velocity. A convex lens-like surface was formed by a chemical etching on the fiber’s tip that had a core diameter of 50 μm. A laser beam that was emitted from the fiber’s tip was focused and formed the measuring volume. This fiber sensor was inserted at an insertion angle of 60° through an injection needle, into the flow duct of an acrylic pipe in which highly concentrated fluid, such as whole blood, was flowing in a pulsatile manner. The flow was modeled after human middle cerebral arterial flow. In this study, the local flow velocity and velocity profile across the duct were measured in the pulsatile flow of a dense suspension of a white pigment. The results were compared both with the results obtained using a fringe-mode LDV and with the results that were calculated on the basis of Womersley's oscillatory flow theory. Consequently, it was found that the local velocity and its profile in the pulsatile flow can be successfully measured using the present fiber-optic LDV sensor, which proved the capability of the sensor as a diagnostic device.
Keywords: Fiber-optic LDV Sensor; Pulsatile Flow; Blood Fluid; Local Velocity Measurement
Authors: Jea Woon Ryu; Chom Kyu Chong; Jae Soo Yoo; Hak Yong Kim
Abstract: Experimental methods such as high-throughput screening have been widely used for the discovery of new drug targets. Genes or proteins close to one another in a network can govern similar functions and diseases. In an effort to predict new disease-related genes or proteins, we hypothesized that a network-neighbor of a disease-related gene or protein could cause the same or similar diseases. First, we constructed a cancer-related human disease network based on the known cancer-related genes and proteins. We obtained 60 diseasomal proteins that appeared to be involved at least cancers and/or other diseases, and chose them as potential drug targets. We then compared the cancer-related target proteins with a cancer-related drug target dataset obtained from DrugBank. Excluding 17 diseasomal proteins that have been already targeted by approved drugs, we identified 43 proteins as putative drug candidates for controlling cancer and/or cancer-related diseases.
Keywords: Co-morbidity; Diseasome; Disease Network; Drug Target Proteome; Protein Network